CaV1.2 Cell Line | NMI TT Pharmaservices

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Electrophysiology

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NMI-TT Contact Person

Dr. Timm Danker

+49 7121 51530 896



Cav1.2 Cell Line Product Infromation

Host cell: CHO-K1
Platforms: Fluorescence, QPatch,
Tested reference inhibitors: Nifedipine, Verapamil, Isradipine
Tested reference activators: FPL64176

Cav1.2 ion channels are expressed in heart, smooth muscle and neurons, and therefore are therapeutic targets in cardiac arrhythmia and hypertension. Due to their key role in shaping the cardiac action potential, they are part of the CiPA-compliant panel of human ion channel to be tested for cardiac safety.


    Key features of our Cav1.2 cell line:
  • stable expression of all three subunits of the native Cav1.2 channel (α1c/β2/α2δ)
  • high success rates and reliable performance in automated patch clamp assays
  • Run-down free recordings
  • Inducible system: easy to maintain in cell culture, adjustable expression level


cav1.2 QPatch dose response data

Cav1.2 QPatch blocked by nifedipine

Cav1.2 stable, run-down free recordings
Cav1.2 effect of FPL64176

 

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