Safety Pharmacology

Langendorff Heart

The Langendorff heart is the best system currently available to determine the influence of compounds on cardiac parameters without interaction with the cardiovascular system.
Additionally, this model makes it possible to estimate the risk of compounds to induce torsade de pointes arrhythmia.

Two models are available:

Standard Model
Proarrhythmic Model

The following electrophysiological and haemodynamic parameters are analyzed:

Left ventricular pressure
Maximum pressure rise
Heartbeat
Coronary flow
Perfusion pressure
QT time with QTc (according to Bazett) or atrial and ventricular focal field potentials (optional)

Further parameters and Poincaré analysis can be carried out upon request.
As standard, four compound concentrations are tested per preparation, in addition to a solvent control and positive control or washout.