Immuno-Oncology Assay Services

Based on an ever growing panel of patient-derived micro-tumours (PDMs) and autologous PBMCs, we have established an advanced and versatile platform of CRO services for immuno-oncology (IO) testing studies of compounds, immuno-therapies and combination treatments.

We offer

  • Cell-based ex vivo studies with dozens of patient-derived micro-tumour models (PDMs) in co-cultures with autologous immune cells (from whole blood-derived PBMCs and/or tumour-derived TILs).

  • Full patient consent and FTO to perform commercial service-based studies.

  • In vitro co-culture assays of patient-derived 3D micro-tumours with immune cells from the very same patients (e.g., PBMCs, antigen-specific T cells) for drug testing.

  • Performance of homogenous reader-based assays as well as high-content microscopy assays.

  • Quantification of cytotoxicity induced by immune cells (e.g. antigen-specific T cells) alone and in combination with investigational compounds, immuno-therapies, oncolytic viruses or combo treatments.

  • Live-cell confocal 3D analysis of PDM infiltration by T lymphocytes.

  • CRISPR-based genome editing of primary T cells.

Immuno-oncology assays with patient-derived ex vivo microtumors and autologous immune cells.