MEA Cardiosensor Services: testing drug effects on cardiac function

Our Cardiosensor is a reliable and rapid system to test for drug effects on cardiac function, including QT-interval prolongation and arrhythmia in vitro.

Cell systems available:

  • Stem-cell derived cardiomyocytes
  • Primary cardiomyocytes from animal models
MEA Cardiosensor | NMI TT Pharmaservices
Beating Stem-cell derived cardiomyocytes
Stem Cell MEA

The assay is based on the extracellular recording of field action potentials (fAPs) of cardiomyocytes in culture with microelectrode arrays (MEAs). fAPs reflect the concerted activation and inactivation of cardiac ion channels, comparable to an electrocardiogram (ECG) in patients and are thus referred to here as “QT-interval” in vitro.

Drug-induced effects on cardiac function can be observed in our test system, as a prolongation of the fAP duration (“QT-interval in vitro”) and/or arrhythmic beating behavior of the electrically coupled cardiomyocytes.